Orthodontic treatment is a dental treatment and can be associated with adverse effects upon the treatment execution. During orthodontic therapy, there are many variables related to the patient which can influence its occurrence. Among the variables related are gender, age, genetic predisposition, psychological type, and malocclusion. It’s necessary to know the detailed particularities to reduce these complications. For instance, there are several physiopathological statuses to consider which can profoundly influence orthodontic therapy. A success treatment depends on the patient’s understanding and physician compliance such as attending periodical appointments, device maintenance, and oral hygiene.